Who We Are
Early Check is a research study offering free additional screening tests in North Carolina.
The study is led by well-known research institutions across the state.
Our Story
Early Check is led by RTI International, an independent nonprofit research institute dedicated to improving the human condition. RTI's headquarters are in Research Triangle Park, North Carolina.
Early Check grew from RTI’s research on newborn screening and focus on improving the lives of individuals and families with special healthcare needs. Shortly after birth, most babies in the United States go through a series of tests, called newborn screening. The tests help doctors act quickly to help babies with treatable rare health conditions that might otherwise go unnoticed and could be deadly.
In 2018, Early Check began offering additional free elective screening for newborns for conditions not part of standard newborn screening. In partnership with the North Carolina State Laboratory of Public Health, the University of North Carolina at Chapel Hill, Duke University, and Wake Forest Baptist Medical Center, Early Check began by screening for a small panel of genetic conditions, including fragile X syndrome and fragile X premutation, spinal muscular atrophy, and Duchenne muscular dystrophy and related neuromuscular conditions, using the same dried blood spot taken during standard newborn screening. In 2023, Early Check expanded to offering screening for over 200 conditions using genome sequencing. Early Check now screens for some of the same conditions as standard newborn screening plus many more and assesses a newborn’s lifetime risk of developing type 1 diabetes. “This is the first study in the U.S. to offer both genome sequencing and genetic risk scores for type 1 diabetes on a statewide basis,” said Holly Peay, Early Check Director. Over time, as we learn more about conditions, the conditions tested by Early Check change.
Our team at RTI brings a range of expertise to newborn screening, including medical genetics, laboratory testing, genetic counseling, health communication, public health, informed decision making, ethics, family adaptation, special education, and child assessment.
“We are in a really lucky time where technology is allowing us to do amazing things and we are able to, with one test on one tiny blood spot, say an enormous amount about the health of a newborn and that is incredibly powerful” – Holly Peay
Our current lab partner is Revvity Omics Inc. Revvity, a CLIA/CAP lab, performs sequencing for Early Check.
Legacy laboratory partners:
Meet Our Team
Our team brings a range of expertise to newborn screening, including medical genetics; laboratory testing; genetic counseling; health communication; public health; informed decision making; ethics; family adaptation; special education; and child assessment.
Click the links below to meet the RTI team and our current partners.